Thermo Fisher Scientific NEDD4 Monoclonal Antibody (OTI6E12), TrueMAB
NEDD4 단백질을 인식하는 Mouse monoclonal 항체로, Western Blot에 최적화됨. Human 시료 반응성 확인됨. 고순도 Affinity chromatography 정제. PBS/BSA/glycerol buffer에 보관되며 -20°C에서 안정적 저장 가능. 연구용 전용 제품.
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Applications
- Western Blot (WB): 1:500 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6E12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 160–460 of human NEDD4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It participates in the degradation pathway of VEGFR-2/KDFR, independent of its ubiquitin-ligase activity.
NEDD4 acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, similar to the Mdm2–p53 regulatory paradigm. It is also involved in viral budding and regulates epithelial Na⁺ channels, which are associated with arterial hypertension.
NEDD4 protein localizes to the sarcolemmal region of muscle fibers. Increased NEDD4 expression is linked to muscle unloading and denervation, as well as decreased Notch1 expression, indicating its role as a down-regulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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