Thermo Fisher Scientific Lymphocyte Activation Gene 3 (LAG3) Monoclonal Antibody (OTI4C11)
인간 LAG3 단백질을 인식하는 단클론 항체로, Western blot 및 유세포분석에 적합합니다. 무보존제 동결건조 형태이며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. T세포 활성 조절 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C11 |
| Immunogen | Full length human recombinant protein of human LAG3 (NP_002277) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
LAG-3 (CD223) is a 70 kDa surface glycoprotein of the immunoglobulin superfamily, homologous to CD4.
It binds MHC class II with higher affinity than CD4 and negatively regulates T cell activation and homeostatic proliferation.
LAG-3 is expressed on activated T cells (including regulatory T cells) and NK cells, with CD8+ T cells showing higher expression levels than CD4+ T cells.
Coexpression of LAG-3 and CD49b identifies Type 1 regulatory T cells (Tr1 cells) in human and mouse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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