Thermo Fisher Scientific Rb1 (Tumor Suppressor Protein) Recombinant Mouse Monoclonal Antibody (rRB1/8060)
Rb1 종양억제 단백질을 인식하는 Thermo Fisher의 재조합 마우스 단일클론 항체. Western blot 및 IHC(P) 적용 가능. 인간 반응성, HEK293 발현, Protein A/G 정제. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 2–4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rRB1/8060 |
| Immunogen | Recombinant human Rb1 protein fragment of 283 amino acid residues |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: A431 or BT-20 cells; human breast or colon carcinoma; HeLa
- Cellular Location: Nucleus
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine residues, but not on tyrosine. It forms complexes with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may regulate transcription, and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene are implicated in cancers of the breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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