Thermo Fisher Scientific Rb1 (Tumor Suppressor Protein) Monoclonal Antibody (RB1, 1754)
Rb1 종양 억제 단백질을 인식하는 단일클론 항체로, 인간 및 생쥐 시료에 반응합니다. IHC(P) 실험에 적합하며, 고순도 Protein A/G 정제 제품입니다. PBS 완충액에 보존되어 있으며, 연구용으로만 사용됩니다.
- 카탈로그번호
- 5925-MSM2-P1ABX
- 판매단위
- pk
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Thermo Fisher Scientific Rb1 (Tumor Suppressor Protein) Monoclonal Antibody (RB1, 1754)
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RB1, 1754 |
| Immunogen | Recombinant human Rb1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C followed by cooling at room temperature for 20 minutes.
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E.
Rb protein may act by regulating transcription, and loss of its function leads to uncontrolled cell growth.
Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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