Thermo Fisher Scientific C-erbB3/HER3 Polyclonal Antibody
Rabbit polyclonal antibody targeting Human C-erbB3/HER3. Validated for WB and IHC applications. Recognizes ErbB3 involved in cell signaling and tumor progression. Supplied as liquid, 0.5 mg/mL, stored at 4°C or -20°C.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–1 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide of c-erbB3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: MCF-7 whole cell lysates
- Cellular location: Secreted and Cell membrane
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6.2 kb mRNA, translated into a 160/180 kDa glycoprotein. It encodes a transmembrane receptor tyrosine kinase that forms heterodimers with other EGF receptor family members. Heterodimerization activates pathways leading to cell proliferation or differentiation.
Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized. One isoform lacks the intermembrane region, is secreted outside the cell, and modulates the activity of the membrane-bound form. Additional splice variants have also been reported but remain incompletely characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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