Thermo Fisher Scientific FPR3 Monoclonal Antibody (7D9B4)
FPR3 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 단클론 항체입니다. Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용에 적합합니다. Human 시료에 반응하며, 단백질 G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7D9B4 |
| Immunogen | Purified recombinant fragment of human FPR3 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091000 |
Target Information
The N-formyl peptide receptor (FPR) family includes three members: FPR, FPR3 (also known as FPRL1, lipoxin A4 receptor, FPRH1, or FPR2), and FPR-like 2 (FPRL2). These are chemotactic G protein-coupled receptors with seven transmembrane domains, expressed on phagocytic leukocytes such as neutrophils and monocytes. Each receptor subtype has specific residues determining ligand specificity.
FPR3 binds to multiple ligands including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide, and the 42 amino acid form of beta amyloid. Upon activation, FPR3 induces migration and calcium mobilization in human monocytes and neutrophils, playing roles in inflammation and host defense. It may also mediate inflammation in prion and Alzheimer’s diseases, making it a potential therapeutic target.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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