Thermo Fisher Scientific HK2 Recombinant Rabbit Monoclonal Antibody (5Z8C3)

Applications

Western Blot (WB)

• Tested Dilution: 1:5,000–1:30,000

ELISA

• Tested Concentration: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLLEIS KRFRKEMEKG LGATTHPTAA VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLWVKVTDN GLQKVEMENQ IYAIPEDIMR

Target Information

In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV.
Hexokinase activity is involved in the first step in several metabolic pathways including phosphorylation of glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway.
Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P.
Hexokinase 2 is the predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.