Thermo Fisher Scientific COL17A1 Polyclonal Antibody
Human COL17A1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 0.3 mg/mL 농도의 액상 형태입니다. 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COL17A1. Recombinant protein control fragment (Product #RP-100377). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640013 |
Product Specific Information
Immunogen sequence:
DGTEVTERIV TETVTTRLTS LPPKGGTSNG YAKTASLGGG SRLEKQSLTH GSSGYINSTG STRGHASTSS YRRAHSPAST LPNSPGSTFE RKTHVTR
Highest antigen sequence identity to the following orthologs:
- Mouse: 92%
- Rat: 92%
Target Information
COL17A1 is the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein and a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane.
COL17A1 is a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). It is localized to tissues containing type I collagen and may help maintain the integrity of the extracellular matrix.
Diseases associated with COL17A1 dysfunction include epithelial recurrent erosion dystrophy and epidermolysis bullosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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