Thermo Fisher Scientific CRB2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CRB2. Recombinant protein control fragment (Product #RP-100819). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CRB2,uniProtId:Q5IJ48-1,ncbiNodeId:9606,antigenRange:720-802,antigenLength:1285,antigenImageFileName:PA5-60462_CRB2_Q5IJ48-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60462_CRB2_Q5IJ48-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640141

Product Specific Information

Immunogen sequence: RWDDGLRHLV MLSFGPDQLQ DLGQHVHVGG RLLAADSQPW GGPFRGCLQD LRLDGCHLPF FPLPLDNSSQ PSELGGRQSW NLT

Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 75%.

Target Information

CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.