Thermo Fisher Scientific NLRP6 Polyclonal Antibody
Human NLRP6 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:20~1:50 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 연구용으로 염증 및 면역 관련 신호전달 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NALP6. Recombinant protein control fragment (Product #RP-97487). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644456 |
Product Specific Information
Immunogen sequence:
GEEPNYPLEL LYCLYETQED AFVRQALCRF PELALQRVRF CRMDVAVLSY CVRCCPAGQA LRLISCRLVA AQEKKKKSLG KRLQASLGGG SSSQGTTKQL PASLLHPLFQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 63%
- Rat: 65%
Target Information
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction.
NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC.
Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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