Thermo Fisher Scientific GABRA4 Monoclonal Antibody (N398A/34), FITC
FITC 형광 표지된 GABRA4 단클론 항체로 인간, 마우스, 랫트 반응성. WB, IHC, ICC/IF 등 다양한 응용에 사용 가능. 높은 특이성과 재현성을 제공하며 단백질 G 정제. 연구용으로만 사용.
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Thermo Fisher Scientific GABRA4 Monoclonal Antibody (N398A/34), FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N398A/34 |
| Immunogen | Fusion protein amino acids 410–450 (Cytoplasmic C-terminus) of rat GABA-A-Receptor Alpha 4 |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | 9.1 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage conditions | 4°C, store in dark |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932188 |
Additional Formats
- Unconjugated (MA5-27701)
- APC (MA5-45733)
- PE (MA5-45736)
- PerCP (MA5-45735)
- Request custom conjugation available
Product Specific Information
- A 1:100 dilution of MA5-45734 was sufficient for detection of GABA-A R, Alpha4 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Detects approximately 60 kDa.
- Does not cross-react with other GABA-A-Receptor Alpha subunits.
- This antibody was formerly sold as clone S398A-34.
Target Information
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain, acting at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
This gene encodes subunit alpha-4, which is involved in the etiology of autism and may increase autism risk through interaction with another subunit, GABA-A receptor beta-1. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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