Thermo Fisher Scientific A2M Recombinant Rabbit Monoclonal Antibody (134)

Applications

ELISA

• Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. To prevent contamination, it is recommended to add sodium azide (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broad immunoreactivity due to the large rabbit immune repertoire

This antibody specifically recognizes Human alpha-2-macroglobulin (A2M).

Target Information

Alpha 2-Macroglobulin (A2M) is an approximately 720 kDa homotetrameric glycoprotein composed of four identical ~180 kDa subunits. Like other alpha-macroglobulins (e.g., C3, C4, and PZP), A2M exhibits an extraordinary binding capacity for diverse ligands, functioning as a humoral defense barrier against foreign peptides in plasma.

A2M acts as a panprotease inhibitor, capturing virtually any proteinase. In the brains of Alzheimer’s disease (AD) patients, A2M has been localized to diffuse amyloid plaques, supporting its potential role in AD pathogenesis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.