Thermo Fisher Scientific GFAP Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

PA1-10004 was made against full-length human recombinant GFAP and works well for western blotting and immunostaining of cell cultures or tissue sections.
This product is supplied as an IgY preparation and not a pure antibody; therefore, concentration is not determined. Dilutions should be optimized by the end user.

Target Information

GFAP (Glial fibrillary acidic protein) is a class III intermediate filament protein specifically expressed in astrocytes and certain astroglia of the central nervous system, satellite cells of peripheral ganglia, and non-myelinating Schwann cells. Neural stem cells also strongly express GFAP.
Antibodies to GFAP serve as useful markers for astrocytic cells and are used to distinguish astrocytes from other glial cells during development. GFAP expression is noted in various brain tumors derived from astrocytic cells, as well as in lens epithelium, Kupffer cells, salivary tumors, and erythrocytes.
Mutations in the GFAP gene cause Alexander disease, a rare disorder of astrocytes. Alternative splicing leads to multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.