Thermo Fisher Scientific CD3/CD25 Antibody Cocktail, FITC, PE

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Product Specific Information

This antibody is a monoclonal mixture of FITC-conjugated CD3 (clone M2AB, isotype IgG1) and PE-conjugated CD25 (clone ITYV, isotype IgG1).

Target Information

T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon, and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.
CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules, mediated in part by a double tyrosine-based motif present in a single copy in the CD3 subunits.
CD3 may play a role in TCR-induced growth arrest, cell survival, and proliferation.

Natural killer (NK) cells are a subpopulation of lymphocytes with properties that distinguish them from B- or T-cells. NK cells are key effectors of innate immunity, releasing cytokines that up-regulate other immunological functions. Monoclonal antibodies have been used to identify different surface antigens present on NK cells, aiding in the classification of functionally distinct subsets.
The Cluster of Differentiation (CD) nomenclature was established to standardize NK cell surface antigen identification. To date, a total of 151 CD clusters and subclusters have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.