Thermo Fisher Scientific CD33 Monoclonal Antibody (FOS)
인간 CD33 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Flow Cytometry에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, 농도는 1 mg/mL입니다. CD33은 급성 골수성 백혈병 연구 및 마이엘로모노사이트 계통 세포 표지에 유용합니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: Assay-dependent
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FOS |
| Immunogen | FMY9S5 cells containing the CD33 gene |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072140 |
Target Information
CD33 is a transmembrane protein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit SHP-1 and SHP-2 protein tyrosine phosphatases, and these motifs also mediate ubiquitin-dependent receptor removal from the cell surface.
CD33 is expressed on cells of the myelomonocytic lineage, binds sialic acid residues in N- and O-glycans, and serves as a therapeutic target for acute myeloid leukemia. It is found on granulocyte and macrophage precursors in bone marrow but not on pluripotent stem cells. CD33 expression on peripheral monocytes makes it a useful marker for distinguishing myelogenous leukemia from lymphoid or erythroid leukemias.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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