Thermo Fisher Scientific OX40L Polyclonal Antibody
Human, Mouse, Non-human primate 반응성을 가진 Rabbit Polyclonal OX40L 항체. Western blot, IHC(P), ICC/IF에 사용 가능. Affinity chromatography로 정제된 액상 항체로, PBS와 50% glycerol에 보관. TNFSF4 단백질의 내인성 수준을 검출.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNFSF4 (Accession P23510), corresponding to amino acid residues M1–F40 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900691 |
Product Specific Information
Antibody detects endogenous levels of total TNFSF4.
Target Information
The tumor necrosis factor superfamily member TNFSF4 is a type II membrane-bound, non-covalently linked homotrimeric protein. It is expressed on antigen-presenting cells such as dendritic cells and activated B-cells, as well as on vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, which is expressed predominantly on CD4+ T cells and certain activated CD8+ T cells.
The TNFRSF4/TNFSF4 interaction functions as a costimulatory signal required for effective communication between antigen-presenting cells and T cells, enhancing cell proliferation, survival, and expression of cytokines such as RANTES, IL-2, IL-3, and IFN-γ. This signaling pathway plays an important role in immunotolerance.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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