Thermo Fisher Scientific GUCY1B3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total Guanylyl Cyclase beta protein.

Target Information

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase: a soluble form (GCS or sGC), which acts as a receptor for nitric oxide, and a membrane-bound receptor form (GC), which serves as a peptide hormone receptor.
The GC-C protein comprises an extracellular domain, a single transmembrane domain, and a cytoplasmic region containing a kinase-like domain and a catalytic domain. It exists as two glycosylated forms: a 130 kDa precursor in the endoplasmic reticulum and a 145 kDa mature form on the plasma membrane.
Ligand binding to the extracellular domain promotes cGMP accumulation. GC-C functions as the receptor for heat-stable enterotoxins from pathogenic E. coli, causing secretory diarrhea, and also binds guanylin and uroguanylin peptides that regulate renal function in response to salt intake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.