Thermo Fisher Scientific PTK2 Monoclonal Antibody (OTI4G7), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase involved in integrin signaling. It plays critical roles in cell spreading, differentiation, migration, apoptosis, and progression from G1 to S phase.
FAK contains a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, where cells attach to the extracellular matrix via integrin receptors.
Upon integrin engagement with fibronectin, FAK undergoes increased tyrosine phosphorylation and interacts with Src, Grb2, and Sos, leading to activation of ERK2 MAP kinase.
Multiple transcript variants exist for the FAK gene, with three full-length isoforms identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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