Thermo Fisher Scientific PERK Polyclonal Antibody
PERK 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, ELISA, IP 등 다양한 응용에 사용 가능. 마우스 PERK(601-1115 aa) 재조합 단백질로 면역화. 고농도(80 mg/mL) 액상 형태로 제공되며, -20°C에서 안정적으로 보관 가능.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution Range |
|---|---|
| Western Blot (WB) | 1:500 – 1:3,000 |
| Immunohistochemistry (IHC) | 1:1,000 |
| ELISA | 1:4,000 – 1:20,000 |
| Immunoprecipitation (IP) | 1:500 – 1:3,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Whole rabbit serum prepared by repeated immunizations with a recombinant fusion protein from amino acids 601–1115 of mouse deltaN PERK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 80 mg/mL |
| Storage Buffer | 0.02 M potassium phosphate / whole serum, pH 7.2, with 0.15 M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Product is stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This antiserum is directed against PERK and reacts with PERK from mouse tissues. Reactivity to other species is unknown.
Target Information
EIF2AK3 (PERK) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein synthesis.
In the case of EIF2AK3, signaling is initiated by misfolded proteins in the endoplasmic reticulum (ER).
Defects in EIF2AK3 cause Wolcott-Rallison syndrome (WRS), a rare autosomal recessive disorder characterized by permanent neonatal or early infancy insulin-dependent diabetes, epiphyseal dysplasia, osteoporosis, growth retardation, and other multisystem manifestations such as hepatic and renal dysfunctions, mental retardation, and cardiovascular abnormalities.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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