Thermo Fisher Scientific Cul2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid repeated freeze/thaw cycles.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• Reacts with human Cullin 2; cross-reactivity with Cul2 from other species not determined.

Target Information

Cullin 2 (CUL2) is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate ubiquitination of target proteins. These complexes collaborate with ARIH1 to regulate substrate ubiquitination. The E3 ligase activity depends on cullin neddylation and is inhibited by association with TIP120A/CAND1. ECS(VHL) complex mediates ubiquitination of hypoxia-inducible factor (HIF).
[Source: UniProt]

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.