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ELK Biotechnology eIF3L rabbit pAb
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eIF3L 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IF, ELISA에 사용 가능. 단백질 합성 개시 복합체 연구에 적합하며, 사람과 생쥐 시료에 반응. -20°C에서 1년 보관 가능.
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ELK Biotechnology ES2246-100UL eIF3L rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES2246-50UL eIF3L rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology eIF3L rabbit pAb
제품명
eIF3L rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EIF3L; EIF3EIP; EIF3S6IP; HSPC021; HSPC025; MSTP005; Eukaryotic translation initiation factor 3 subunit L; eIF3l; Eukaryotic translation initiation factor 3 subunit 6-interacting protein; Eukaryotic translation initiation factor 3 subunit E |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IF3EI (AA range: 1-50) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 67 kD |
| Gene ID (Human) | 51386 |
| Human Swiss-Prot No | Q9Y262 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human; Mouse |
Background
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5 to form the 43S preinitiation complex (43S PIC). It stimulates mRNA recruitment to the 43S PIC and scanning for AUG recognition. The eIF-3 complex also participates in disassembly and recycling of posttermination ribosomal complexes, preventing premature joining of 40S and 60S subunits prior to initiation.
- Complex composition: eIF-3 consists of 13 subunits (EIF3A–M).
- Modular structure:
- Module A: EIF3A, EIF3B, EIF3G, EIF3I
- Module B: EIF3F, EIF3H, EIF3M
- Module C: EIF3C, EIF3D, EIF3E, EIF3K, EIF3L
- Interactions: EIF3C binds EIF3B and EIF3H to link modules; EIF3J is a labile subunit binding via EIF3B.
- Biological relevance: Interacts with RPS6KB1 under nutrient depletion; mitogenic stimulation activates FRAP1–RAPTOR complex, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
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