
ELK Biotechnology DREAM rabbit pAb
DREAM 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 및 생쥐 시료 반응. Calsenilin/KCNIP3 합성 펩타이드로 면역화. 세포질, 세포막, 소포체, 골지체, 핵 등 다양한 세포 위치에서 발현 단백질 검출에 적합.
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제품명
DREAM rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | KCNIP3; CSEN; DREAM; KCHIP3; Calsenilin; A-type potassium channel modulatory protein 3; DRE-antagonist modulator; Kv channel-interacting protein 3; KChIP3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Calsenilin/KCNIP3 (AA range: 29-78) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 29 kDa |
| Gene ID (Human) | 30818 |
| Human Swiss-Prot No. | Q9Y2W7 |
| Cellular Localization | Cytoplasm; Cell membrane (lipid-anchor); Endoplasmic reticulum; Golgi apparatus; Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2, associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium-binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq, Jul 2008)
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