
ELK Biotechnology DNA Ligase III rabbit pAb
DNA Ligase III rabbit pAb는 인간, 마우스, 랫트 시료에서 DNA 결합 효소를 검출하는 폴리클로날 항체입니다. WB와 ELISA에 적합하며, 미토콘드리아 및 핵 내 단백질 발현 연구에 활용됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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DNA Ligase III rabbit pAb
제품 개요
DNA Ligase III는 DNA 복구 과정에서 DNA 말단을 연결하는 효소로, 미토콘드리아와 핵 내에서 모두 발현됩니다. 본 항체는 DNA Ligase III 단백질을 인식하는 토끼 폴리클로날 항체입니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | DNA Ligase III rabbit pAb |
| Alternative Names | LIG3; DNA ligase 3; DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from DNA Ligase III (AA range: 110–190) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 100 kDa |
| Gene ID (Human) | 3980 |
| Human Swiss-Prot No. | P49916 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Isoform 1: Mitochondrion (contains N-terminal mitochondrial transit peptide) Isoform 2: Mitochondrion (contains N-terminal mitochondrial transit peptide) Isoform 3: Nucleus (lacks N-terminal mitochondrial transit peptide) Isoform 4: Nucleus (lacks N-terminal mitochondrial transit peptide) |
Background
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends, but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus. Translation initiation from the upstream start codon allows transport to the mitochondria, while initiation from a downstream start codon allows transport to the nucleus. Additionally, alternate transcriptional splice variants encoding different isoforms have been characterized. (RefSeq, Jul 2008)
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