ELK Biotechnology DMPK rabbit pAb
DMPK 단백질을 인식하는 토끼 다클론 항체로, Western blot 및 ELISA에 적합합니다. 인간, 생쥐, 랫트 시료에서 반응하며 70kDa 밴드를 검출합니다. 합성 펩타이드(AA 11-60)로 면역화되었으며, -20°C에서 1년 보관 가능합니다.
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- pk
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ELK Biotechnology DMPK rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | DMPK rabbit pAb |
| Alternative Names | DMPK; DM1PK; MDPK; Myotonin-protein kinase; MT-PK; DM-kinase; DMK; DM1 protein kinase; DMPK; Myotonic dystrophy protein kinase |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DMPK. AA range: 11-60 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kD |
| Gene ID (Human) | 1760 |
| Human Swiss-Prot No. | Q09013 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Endoplasmic reticulum membrane; single-pass type IV membrane protein; cytoplasmic side. Nucleus outer membrane; single-pass type IV membrane protein; cytoplasmic side. Mitochondrion outer membrane; single-pass type IV membrane protein. Sarcoplasmic reticulum membrane. Cell membrane. Cytoplasm, cytosol. Localizes to sarcoplasmic reticulum membranes of cardiomyocytes. Isoform 1 and 3: Mitochondrion membrane. |
Background
The protein encoded by this gene is a serine-threonine kinase closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3′ untranslated region of this gene contains 5–38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50–5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts gene expression in this region. Several alternatively spliced transcript variants have been described, though the full-length nature of some variants remains undetermined. (RefSeq, Jul 2016)
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