ELK Biotechnology DCAMKL2 rabbit pAb

제품명

DCAMKL2 rabbit pAb

제품 개요

DCAMKL2는 단백질 키나아제 초가족 및 doublecortin 패밀리에 속하는 단백질로, 미세소관 결합 및 중합 조절에 관여합니다. 본 항체는 인간 DCLK2 유래 합성 펩타이드(AA 1-50)를 면역원으로 제작된 토끼 폴리클로날 항체입니다. 세포질 및 세포골격 내 단백질 검출에 적합합니다.

제품 사양

Background

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The encoded protein contains two N-terminal doublecortin domains that bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain homologous to Ca²⁺/calmodulin-dependent protein kinase, and a serine/proline-rich domain mediating multiple protein–protein interactions. Microtubule-polymerizing activity is independent of kinase activity. Mouse studies indicate that DCX and DCLK2 share functions in hippocampal organization, and their absence leads to severe epileptic phenotypes and lethality, similar to lissencephaly in humans.