ELK Biotechnology Cystatin 11 rabbit pAb
Cystatin 11 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 사용 가능. 인간, 랫드, 마우스 반응성. 합성 펩타이드 면역원으로 제작되었으며, 정자 표면 부위에 주로 발현. -20°C에서 1년 보관 가능.
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Cystatin 11 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cystatin 11 rabbit pAb |
| Alternative Names | CST11; CST8L; Cystatin-11 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CST11 (AA range: 81-130) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 17 kD |
| Gene ID (Human) | 140880 |
| Human Swiss-Prot No. | Q9H112 |
| Cellular Localization | Secreted. Probably secreted into the epididymis lumen, where it localizes to the outer surface of sperm. Specifically localizes to the postacrosomal and tail regions of sperm. |
| Species Reactivity | Human; Rat; Mouse |
Background
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some members are active cysteine protease inhibitors, while others have lost or never acquired this inhibitory activity.
There are three inhibitory families in the superfamily: type 1 cystatins (stefins), type 2 cystatins, and kininogens.
Type 2 cystatin proteins are cysteine proteinase inhibitors found in various human fluids and secretions.
The cystatin locus on chromosome 20 contains most type 2 cystatin genes and pseudogenes.
This gene encodes an epididymal-specific protein with antimicrobial activity against E. coli.
Alternative splicing yields two variants encoding distinct isoforms.
(Information provided by RefSeq, Sep 2014)
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