ELK Biotechnology CYP2D6 rabbit pAb
CYP2D6 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 Cytochrome P450 2D6 유래 펩타이드로 면역화됨. 약물 대사 연구 및 효소 발현 분석에 적합. -20°C에서 1년 보관 가능.
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제품명
CYP2D6 rabbit pAb
제품 개요
CYP2D6 단백질을 인식하는 토끼 폴리클로날 항체입니다. 인간 Cytochrome P450 2D6 유래 합성 펩타이드로 면역화되었으며, 다양한 응용 분야(WB, IHC, IF, ELISA)에 사용 가능합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CYP2D6 rabbit pAb |
| Alternative Names | CYP2D6; CYP2DL1; Cytochrome P450 2D6; CYPIID6; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Cytochrome P450 2D6 (AA range: 251–300) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| Gene ID (Human) | 1565 |
| Human Swiss-Prot No. | P10635 |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane |
| Species Reactivity | Human |
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics, antitussives, beta adrenergic blocking agents, antiarrhythmics, and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme’s substrates. Some individuals with this phenotype have no functional protein due to null alleles or gene absence.
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