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ELK Biotechnology CYP27A1 rabbit pAb
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CYP27A1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 유래 합성 펩타이드(AA 101-150)로부터 제작. 미토콘드리아 내막 단백질 검출에 적합하며, 콜레스테롤 대사 연구에 활용 가능.
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- pk
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ELK Biotechnology ES2096-100UL CYP27A1 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES2096-50UL CYP27A1 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology CYP27A1 rabbit pAb
제품명
CYP27A1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CYP27A1; CYP27; Sterol 26-hydroxylase; mitochondrial; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; Cytochrome P-450C27/25; Cytochrome P450 27; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Cytochrome P450 27A1 (AA range: 101–150) |
| Host | Rabbit |
| Storage | -20°C for 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kDa |
| Gene ID (Human) | 1593 |
| Human Swiss-Prot No. | Q02318 |
| Cellular Localization | Mitochondrion inner membrane; Peripheral membrane protein. Post-translationally targeted to mitochondria. Requires TOMM70, TOMM20, and TOMM22 for translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane-extrinsic protein. |
| Species Reactivity | Human; Rat; Mouse |
Background
Cytochrome P450 family 27 subfamily A member 1 (CYP27A1) is a mitochondrial enzyme belonging to the cytochrome P450 superfamily. These monooxygenases catalyze reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids. CYP27A1 oxidizes cholesterol intermediates during bile acid synthesis, playing a crucial role in cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.
(Information provided by RefSeq, Jul 2008)
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