Thermo Fisher Scientific Caspase 7 Monoclonal Antibody (Mch3 1-1-11)
Caspase 7 단백질을 인식하는 Mouse monoclonal antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 Immunocytochemistry에 사용 가능하며, 세포 사멸 연구에 적합합니다. 비결합형 액상 시약으로 4°C 또는 -20°C에 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Mch3 1-1-11 |
| Immunogen | Full-length recombinant human Caspase 7 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.1% Sodium Azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_568480 |
Product Specific Information
Suggested positive controls include HeLa whole cell lysate, antigen standard for CASP7 (transient overexpression lysate), HeLa and Jurkat whole cell extracts, and Jurkat whole cell lysate.
Target Information
Caspase 7 belongs to a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. Apoptotic caspases are involved in cell death, while inflammatory caspases are related to immune responses. Caspase 7 acts as an executioner caspase activated by initiator caspases, leading to cleavage of cellular substrates during apoptosis. It shares homology with caspases 1 and 3 and the C. elegans protein CED-3. Alternative splicing produces three isoforms of Caspase 7, and its activity can be inhibited by XIAP expression. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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