ELK Biotechnology Claudin-3 rabbit pAb
Claudin-3 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 세포 간 밀착연접 연구에 적합하며, 인간, 생쥐, 랫트 시료에 반응. -20°C에서 1년 보관 가능.
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제품명
Claudin-3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CLDN3; C7orf1; CPETR2; Claudin-3; Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; Rat ventral prostate.1 protein homolog; hRVP1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Claudin 3 (AA range: 171–220) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 25 kDa |
| Gene ID (Human) | 1365 |
| Human Swiss-Prot No | O15551 |
| Cellular Localization | Cell junction, tight junction; Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human, Mouse, Rat |
Background
Tight junctions are one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions consist of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet.
The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It also functions as a low-affinity receptor for Clostridium perfringens enterotoxin and shares amino acid sequence similarity with a putative apoptosis-related protein found in rat. (RefSeq, Jul 2008)
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