ELK Biotechnology Chemokine Receptor D6 rabbit pAb

Chemokine Receptor D6 rabbit pAb

Supplier: ELK Biotechnology

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세포 내 위치 (Cellular Localization)

Early endosome, recycling endosome, cell membrane; multi-pass membrane protein. Predominantly localizes to endocytic vesicles and, upon ligand stimulation, is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor and is targeted for degradation, while the receptor is recycled back to the cell membrane.

Background

This gene encodes a beta chemokine receptor predicted to be a seven-transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for recruitment of effector immune cells to inflammation sites. Expression occurs in various tissues and hemopoietic cells. Expression in lymphatic endothelial cells and overexpression in vascular tumors suggest roles in chemokine-driven leukocyte recirculation and vascular tumor development. This receptor binds most beta-chemokine family members, though its specific function remains unclear. The gene is mapped to chromosome 3p21.3, a region including a cluster of chemokine receptor genes. (RefSeq, Jul 2008)

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