ELK Biotechnology CFTR rabbit pAb

제품명

CFTR rabbit pAb

제품 개요

CFTR rabbit polyclonal antibody는 인간 CFTR 단백질을 인식하도록 제작된 항체로, 다양한 응용 분야(WB, IHC, IF, ELISA)에 사용됩니다. 본 항체는 합성 펩타이드(AA 711-760)를 면역원으로 사용하여 생산되었으며, 높은 특이성과 재현성을 제공합니다.

제품 상세 정보

세포 내 위치 (Cellular Localization)

Apical cell membrane; multi-pass membrane protein.
Early endosome membrane; multi-pass membrane protein.
Cell membrane; multi-pass membrane protein.
Recycling endosome membrane; multi-pass membrane protein.
Endoplasmic reticulum membrane; multi-pass membrane protein.
Nucleus.
The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:17462998, PubMed:19398555, PubMed:20008117).
In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia (PubMed:22207244).
In Sertoli cells, a processed product is detected in the nucleus (By similarity).
ER stress induces GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR.

Background

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
CFTR protein is a member of the MRP subfamily involved in multi-drug resistance and functions as a chloride channel, controlling the regulation of other transport pathways.
Mutations in this gene are associated with cystic fibrosis and congenital bilateral aplasia of the vas deferens.
Alternatively spliced transcript variants have been described, many resulting from mutations in this gene.
[provided by RefSeq, Jul 2008]