ELK Biotechnology c-Fms rabbit pAb
CSF1R 단백질을 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 사용 가능. 인간, 랫트, 마우스 반응성. 세포막 단백질 검출에 적합하며, -20°C에서 1년 보관 가능.
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ELK Biotechnology c-Fms rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | c-Fms rabbit pAb |
| Alternative Names | CSF1R; FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD antigen CD115 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CSFR (AA range: 781–830) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kD |
| GeneID (Human) | 1436 |
| Human Swiss-Prot No | P07333 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is the receptor for colony stimulating factor 1 (CSF1), a cytokine that controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of CSF1. Ligand binding activates the receptor kinase through oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and a member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. (RefSeq, Dec 2013)
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