Thermo Fisher Scientific CD34 Monoclonal Antibody (OTI39B1), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on various stem cell populations. It functions as a stem cell marker with reversible expression on human hematopoietic stem cells. CD34 may act as a surface receptor involved in receptor-mediated endocytosis and regulation of adhesion, differentiation, and proliferation of hematopoietic progenitors.

It may also serve as an adhesion molecule facilitating stem cell attachment to the bone marrow extracellular matrix or stromal cells. CD34 can act as a scaffold for lineage-specific glycans, enabling binding to lectins on stromal or marrow components, and may present carbohydrate ligands to selectins. The intracellular domain is a phosphorylation site for protein kinase C, suggesting a role in signal transduction.

Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.