Thermo Fisher Scientific IKZF3 Monoclonal Antibody (OTI4C9), TrueMAB
Human IKZF3(Aiolos) 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot 및 IHC(P)에서 검증됨. Lyophilized 형태로 제공되며, 재구성 후 약 1 mg/mL 농도. B 림프구 발달 및 분화 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–301 of human IKZF3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The IKZF3 gene encodes a member of the Ikaros family of zinc-finger proteins. Ikaros, Aiolos, and Helios are hematopoietic-specific transcription factors regulating lymphocyte development.
IKZF3 is a transcription factor critical for B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos participate in chromatin remodeling. Regulation of gene expression by Aiolos involves sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers.
At least six alternative transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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