Thermo Fisher Scientific DNER Monoclonal Antibody (298306)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, no cross-reactivity with recombinant human DNER is observed.
• Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system.
DNER contains ten extracellular EGF-like domains highly homologous to those of the Notch ligand, Delta.
In the cerebellum, DNER is predominantly expressed in Purkinje cells and mediates neuron-glia interaction during astrocytogenesis through direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts.
This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis.
DNER is crucial for the functional and morphological maturation of Bergmann glia.
DNER-knockout mice show motor discoordination and cerebellar morphogenesis retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.