Thermo Fisher Scientific MLLT10 Polyclonal Antibody
MLLT10 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간 및 마우스 시료에 반응하며, 고순도의 Affinity chromatography 정제 항체입니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MLLT10 (Accession P55197), corresponding to amino acid residues S217–Y267 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850576 |
Product Specific Information
Antibody detects endogenous levels of total AF10.
Target Information
Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in the translocations is MLL. MLLT10 is the partner gene to MLL1 involved in t(10;11)(p12;q23) translocations.
In leukemia patients, the t(10;11)(p12;q23) translocation fuses MLL1, a SET domain-containing histone methyltransferase, to the MLLT10 gene. The MLLT10 gene encodes a 1,027-amino acid protein with an N-terminal zinc finger and a C-terminal leucine zipper domain.
MLLT10 is one of the few MLL partner genes independently rearranged with a third gene, CALM, in the t(10;11)(p12;q14) translocation. Chimeric fusion proteins MLL/AF10 and CALM/AF10 retain the leucine zipper motif of MLLT10, which interacts with GAS41, a protein amplified in glioblastoma. GAS41 interacts with INI1, a component of the SWI/SNF complex involved in chromatin remodeling and transcription regulation. Retention of the leucine zipper suggests these chimeric proteins may interfere with normal gene regulation via chromatin remodeling complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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