Thermo Fisher Scientific NSFL1C Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal NSFL1C 항체로, Western blot 및 Immunocytochemistry에 적합. 항원 친화 크로마토그래피로 정제된 고순도 제품이며, 액상 형태로 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human NSFL1C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2720714 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
p47, also known as NSFL1C, UBX1, UBXD10, or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the Golgi apparatus (specifically to Golgi stacks). It contains one SEP domain and one UBX domain.
Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP. It is required for the fragmentation of Golgi stacks during mitosis and subsequent reassembly after mitosis.
p47 is phosphorylated during mitosis, which inhibits p47-Golgi interaction and is required for proper Golgi stack formation and cisternal regrowth. Human p47 shares 89% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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