Thermo Fisher Scientific Progesterone Receptor Monoclonal Antibody (PgR636)
인간 및 생쥐 프로게스테론 수용체(A/B forms) 검출용 단클론 항체. IHC(P), WB, ICC/IF 등 다양한 응용에 적합. 비결합형, 액상 형태로 4°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:20 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PgR636 |
| Immunogen | Formalin-fixed recombinant full-length A-form of human progesterone receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Tissue culture supernatant |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10979638 |
Product Specific Information
MA5-12581 targets the Progesterone Receptor in IHC (P) applications and shows reactivity with human samples.
The immunogen is a formalin-fixed recombinant full-length A-form of the human progesterone receptor.
This antibody detects both A and B forms of the progesterone receptor from human and mouse in western blot, immunofluorescence, and immunohistochemistry.
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, a key hormone in reproductive processes related to pregnancy establishment and maintenance.
PR exists as two isoforms:
- Form A (94 kDa)
- Form B (120 kDa)
PR-B is transcriptionally active, responsible for gene activation related to endometrial maintenance, pregnancy, and ovulation inhibition.
PR-A lacks 165 amino acids at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, conformational changes enable dimerization and DNA binding to progesterone response elements (PRE), initiating transcriptional activation.
A null mutation in the PGR gene leads to reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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