Thermo Fisher Scientific CDKL2 Monoclonal Antibody (OTI12C2), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Signal transduction pathways activated by growth factors, hormones, and neurotransmitters are mediated by MAP kinases ERK1 and ERK2, which are regulated by dual phosphorylation at specific tyrosine and threonine residues within a Thr-Glu-Tyr motif.
The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group and closely related to p42 KKIALRE. It is predominantly expressed in testis, kidney, brain, and lung.
KKIAMRE contains the conserved MAP kinase dual phosphorylation motif (Thr-Asp-Tyr) and is activated by EGF treatment. Unlike other MAP kinases, EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in this motif.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.