Thermo Fisher Scientific SLC22A2 Polyclonal Antibody
Thermo Fisher Scientific의 SLC22A2 폴리클로날 항체는 마우스 시료에 반응하며, Western blot 및 ELISA에 적합합니다. Rabbit IgG로 제작되었으며, 고순도의 Affinity Chromatography 정제 방식으로 생산되었습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 44–140 of human SLC22A2 (NP_003049.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.38 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805680 |
Product Specific Information
- Immunogen sequence: GFTPDHRCRS PGVAELSLRC GWSPAEELNY TVPGPGPAGE ASPRQCRRYE VDWNQSTFDC VDPLASLDTN RSRLPLGPCR DGWVYETPGS SIVTEFN
- Positive Samples: Mouse kidney
- Cellular Location: Membrane, Multi-pass membrane protein
Target Information
Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs, and other xenobiotics.
The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop.
In humans:
- OCT1: Primarily expressed in the liver
- OCT2 (SLC22A2): Expressed in the kidney, localizing to the basolateral and luminal membranes of the distal and proximal tubules
- OCT3: Expressed in the placenta, skeletal muscle, prostate, aorta, and liver
OCT2 mediates the pH-sensitive tubular uptake of organic compounds from circulation. An additional splice variant exists for OCT2, namely OCT2-A.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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