Thermo Fisher Scientific PTPN22 Polyclonal Antibody
PTPN22 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. WB, ICC/IF, ELISA에 사용 가능하며 인체, 마우스, 랫트에 반응. 액상 형태로 -20°C 보관. 자가면역 질환 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–90 of human PTPN22 (NP_0365434) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.15 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805679 |
Product Specific Information
- Immunogen sequence: MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE KPKNIKKNRY KDILPYDYSR VELSLITSDE DSSYINANFI
- Positive Samples: Jurkat, Mouse spleen
- Cellular Location: Cytoplasm
Target Information
The protein tyrosine phosphatase PTPN22 (also known as PTP22, LYP, PEP, formerly PTPN8) is a genetic variant associated with increased risk of autoimmune diseases such as type 1 diabetes and rheumatoid arthritis.
A missense SNP in PTPN22 encodes a hematopoietic-specific phosphatase known as Lyp. The risk allele appears in approximately 17% of the general Caucasian population and about 28% of individuals with rheumatoid arthritis.
This variant is thought to disrupt the P1 proline-rich motif essential for interaction with the SH3 domain of CSK (cytoplasmic tyrosine kinase), potentially altering T cell activation regulation.
PTPN22 may act as an effector or regulator of CSK in T cells and other hematopoietic cells.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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