Thermo Fisher Scientific MCM10 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MCM10 protein. Validated for IHC (paraffin) with 1:100–1:200 dilution. Supplied as liquid, affinity-purified, 1.3 mg/mL concentration. Suitable for research use in DNA replication studies.
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Applications
Tested Applications and Dilutions
- Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein of human MCM10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.3 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2688389 |
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in replication fork formation and recruitment of other DNA replication-related proteins. It interacts with MCM2, MCM6, and the origin recognition protein ORC2. This protein is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies in Xenopus suggest its chromatin binding occurs after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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