Thermo Fisher Scientific DEDD2 Polyclonal Antibody

Thermo Fisher Scientific DEDD2 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:100

Product Specifications

Target Information

Apoptotic signals are often triggered by cell surface death receptors through protein–protein interactions mediated by conserved domains such as the death effector domain.
A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD.

DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, suggesting that DEDD2 may target caspase-8 to the nucleus and play a critical role in death receptor-induced apoptosis.
At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.