Thermo Fisher Scientific DEDD2 Polyclonal Antibody
DEDD2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며 IHC(P) 등 다양한 연구용 응용에 적합. 액상 형태로 공급되며 고순도 친화 크로마토그래피 정제. 세포 사멸 관련 신호 연구에 활용 가능.
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Thermo Fisher Scientific DEDD2 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein of human DEDD2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2688485 |
Target Information
Apoptotic signals are often triggered by cell surface death receptors through protein–protein interactions mediated by conserved domains such as the death effector domain.
A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD.
DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, suggesting that DEDD2 may target caspase-8 to the nucleus and play a critical role in death receptor-induced apoptosis.
At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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