Thermo Fisher Scientific Wilms Tumor 1 (WT1) Recombinant Mouse Monoclonal Antibody (rWT1, 857)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL
• Publications: References

Peptide Array (Array)

• Tested Dilution: Assay-dependent
• Publications: References

Product Specifications

Product Specific Information

Immunohistochemistry (PFA fixed):

• Incubate antibody for 30 min at room temperature (RT).
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at RT for 20 min.

Target Information

The Wilms Tumor 1 (WT1) gene encodes one of the WPP domain-interacting proteins required for RanGAP nuclear envelope association in root tip cells.
Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly.
Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs).
Wilms Tumor 1 and WIT2 have been identified as a second family of CC-TMD proteins that are structurally similar yet distinct from the WIP family, and are required for RanGAP nuclear envelope association in root tip cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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