Thermo Fisher Scientific Wilm`s Tumor 1 (WT1) (Wilm`s Tumor and Mesothelial Marker) Monoclonal Antibody (WT1/857, 6F-H2)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Product Specifications

Target Information

The Wilms Tumor 1 (WT1) gene encodes one of the WPP domain-interacting proteins required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. RanGAP is critical for establishing the RanGTP/RanGDP gradient across the nuclear envelope and is associated with its outer surface in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association requires plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WT1 and WIT2 form a second family of CC-TMD proteins that are structurally similar yet distinct from WIPs and are necessary for RanGAP nuclear envelope association in root tip cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.