Thermo Fisher Scientific beta Adducin Polyclonal Antibody
Thermo Fisher Scientific의 beta Adducin Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 WB, IHC, ICC 등 다양한 응용에 적합합니다. KLH 결합 합성 펩타이드로 면역생성된 rabbit IgG 폴리클로날 항체로, 고순도 Protein A 정제 및 액상 형태로 제공됩니다.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human beta Adducin protein (amino acids 401–500) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adducins are heteromeric proteins composed of alpha, beta, and gamma subunits, encoded by distinct genes. They are membrane skeletal proteins involved in spectrin-actin network assembly in erythrocytes and epithelial cell junctions.
While alpha and gamma adducins are ubiquitously expressed, beta adducin expression is restricted to brain and hematopoietic tissues.
Adducin purified from human erythrocytes is a heterodimer of alpha and beta subunits. Polymorphisms in these subunits are linked to blood pressure regulation in hypertension models.
Each subunit has two domains: a protease-resistant globular N-terminal region and a protease-sensitive C-terminal region containing phosphorylation sites for protein kinase C, a calmodulin-binding site, and regions required for spectrin-actin association.
Various alternatively spliced beta adducin mRNAs encode different isoforms, whose functions are not fully understood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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