Thermo Fisher Scientific Human FGFR2a (IIIc) Fc Recombinant Protein, PeproTech
Recombinant Human FGFR2a (IIIc) Fc-tagged protein for functional and proliferation assays. High purity (≥95%) and specific activity (≥1×10⁷ units/mg). Expressed in CHO cells, lyophilized form, endotoxin <1 EU/µg. For research use only.
- 카탈로그번호
- 160-03-xxx (6개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
6개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human FGFR2a (IIIc) Fc Recombinant Protein, PeproTech
Applications
- Functional Assay (Functional)
Tested Dilution
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | CHO cells |
| Amino Acid Sequence | RPSFSLVEDT TLEPEEPPTK YQISQPEVYV AAPGESLEVR CLLKDAAVIS WTKDGVHLGP NNRTVLIGEY LQIKGATPRD SGLYACTASR TVDSETWYFM VNVTDAISSG DDEDDTDGAE DFVSENSNNK RAPYWTNTEK MEKRLHAVPA ANTVKFRCPA GGNPMPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV VPSDKGNYTC VVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKAAGVNTTD KEIEVLYIRN VTFEDAGEYT CLAGNSIGIS FHSAWLTVLP APGREKEITA SPDYLEGGPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK |
| Tag | Fc-tag |
| Molecular Weight | 65.6 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 95% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Determined by cell proliferation assay using Balb/c 3T3 cells. Expected ED50 ≤ 0.1 ng/ml (≥1×10⁷ units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human FGFR2a (IIIc) is a 65.6 kDa protein containing 589 amino acids. Under reducing conditions, FGFR2a migrates between 100–110 kDa on SDS-PAGE gel.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
The FGF family plays a central role in prenatal development, postnatal growth, and tissue regeneration by promoting cellular proliferation and differentiation.
FGF ligands bind to type I transmembrane tyrosine kinase receptors, leading to dimerization and activation through autophosphorylation of tyrosine residues.
Four genes encode related FGF receptors (FGFR1–4). Alternative splicing of mRNAs generates multiple forms of FGFR1–3, which differ in ligand-binding specificity.
For instance, FGFR1a (IIc) interacts mainly with FGF1 and FGF2. Splicing events produce alpha isoforms (three Ig domains) and beta isoforms (two Ig domains). Only alpha isoforms exist for FGFR3 and FGFR4.
Additional splicing of FGFR1–3 generates receptors with alternative IgIII domains (IIIb and IIIc).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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