Thermo Fisher Scientific Phospho-Chk1 (Ser317) Recombinant Rabbit Monoclonal Antibody (Chk1S317-G1), FITC
Phospho-Chk1 (Ser317) 인산화 부위를 특이적으로 인식하는 FITC 결합 토끼 단클론 항체. 인간 및 생쥐 시료에 반응하며, Flow Cytometry에 적합. 단백질 A/G 정제, PBS + BSA 완충액, 4°C 암소 보관.
- 판매단위
- pk
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Applications
- Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Chk1S317-G1 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser317 of human phospho Chk1 |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897259 |
Additional Formats
- Unconjugated (MA5-37065)
- APC (MA5-37068)
- PE (MA5-37066)
- Custom conjugation available on request
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network and functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by CHK1 inhibition, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, while normal cells remain arrested in G1. Thus, CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer therapy, particularly as approximately 50% of human cancers are p53-deficient.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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