Thermo Fisher Scientific Phospho-Nephrin (Tyr1217) Polyclonal Antibody

Applications

Product Specifications

Target Information

Primary steroid resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2.

Nephrin, a recently identified protein, is a member of a group of podocyte proteins that constitute a major component of the slit diaphragm, especially in the foot process. Nephrin, a cell adhesion molecule, may play a crucial role in maintaining the glomerular filtration barrier.

Mutations in the gene for Nephrin reportedly lead to congenital nephrosis. Three novel podocyte proteins—Podocin, Nephrin, and alpha Actinin 4—have been identified in congenital and experimental models of proteinuria.

Nephrin’s role in anti-apoptotic activity in the podocyte slit diaphragm is believed to be associated with VEGF signaling. It may anchor the podocyte slit diaphragm to the actin cytoskeleton and play a role in kidney glomerular filtration barrier development or function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.